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Granuloma inguinale

Cause

Bacteria - Calymmatobacterium granulomatis.

Distribution

Countries with warm humid climates for example, Africa, Papua New Guinea, Southern India and South USA.

Transmission

 Sexual

Incubation

Uncertain, probably long.

Symptoms

Red painless nodule which develops into a raised ulcer with a raw beefy surface.

Diagnosis
  • Physical examination.
  • Microscopic examination of crushed tissue.
  • Skin biopsy.
Treatment

Tetracycline and co-trimoxazole (a sulphonamide containing antibiotic) by mouth or streptomycin injections.

Complications
  • Severe scarring causing obstruction to the flow of lymph (a tissue fluid). This may lead to genital elephantiasis (swelling and distortion of the genitals).
  • Untreated infection may spread to the surrounding skin and to the rectum.
  • Cancerous change may develop in long-standing untreated cases.